Translational genomics: the path from genomic insight to clinical applications, licensed drugs and treatment decisions through case-examples
The Centre organised a meeting of international and national experts to consider developments in translational genomics, particularly focusing on case examples of drugs and interventions that have made successful transitions to the market or clinic. Held in January 2013 at the Royal College of Physicians, the programme included pharmacogenetic testing, gene therapy, potentially personalised monoclonal antibodies, the validation of biomarkers that are predictive of drug-response, health technology assessment of such biomarkers (companion diagnostics), and the educational challenges presented by this fast expanding field. As well as presentations, the discussions considered policy implications (particularly for the NHS) and considered topics such as the impact on public health, clinical practice and commissioning; comparative effectiveness and value for money; and post-marketing surveillance.
Presenters agreed that the event could be recorded and transcripts and edited powerpoint slides and pdfs made available. This slides and pdfs are being checked and will be posted here as each presenter confirms final agreement, or the Centre will post a summary of their presentations.
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Introduction
Sir Richard Thompson
President, Royal College Of Physicians
Length: 1 minute 48 seconds
Clinical Pharmacogenomics: Implications of new developments for the NHS
Professor Munir Pirmohamed
Professor of Clinical Pharmacology, NHS Chair of Pharmacogenetics
Length: 33 minutes 7 seconds
- Download the session PowerPoint
- Download the video transcriptIRESSA: A case-study in personalised medicine in the management of lung cancer
Dr Rose McCormack
AstraZeneca
Length: 26 minutes 19 seconds
Stratified Medicine at Cancer Research UK
Professor Peter Johnson
Chief Clinician, Cancer Research UK
Length: 25 minutes 18 seconds
HTA of companion diagnostics: Informing the NHS
Dr Elisabeth George
Associate Director - Appraisals, National Institute for Health and Clinical excellence
Length: 26 minutes 40 seconds
Gene therapy and therapeutic gene editing: What are the predictors of success?
Professor Bobby Gaspar
Professor of Padeiatrics and Immunology, UCL Institute of Child Health
Length: 36 minutes 6 seconds
Impact on patients
Alastair Kent
Director, Genetic Alliance UK
Length: 10 minutes 7 seconds
Impact on patients
Dr Vanessa Potter
Consultant Oncologist, Nottingham University Hospitals
Length: 5 minutes 14 seconds
Impact on healthcare products regulation
Dr June Raine
Medicines and Healthcare Products Regulatory Agency
Length: 6 minutes 34 seconds
Impact on genomic medicines
Professor Adrian Towse
Director, Office of Health Economics
Length: 5 minutes 10 seconds
Impact on industry
Dr Mike Hardman
AstraZeneca
Length: 3 minutes 14 seconds
Impact on the Department of Health
Dr Mark Bale
Department of Health
Length: 7 minutes 19 seconds
Impact on the genetics laboratory
Professor Mike Griffiths
Director, West Midlands Regional Genetics Laboratory
Length: 5 minutes 11 seconds
Impact on medical students
Professor Patrick Maxwell
Dean, Cambridge University Medical School
Length: 7 minutes
Implications for pharmacy education
Professor Rex Tyrell
Head, School of Pharmacy, University of Bath
Length: 3 minutes 17 seconds
